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David Schiff1

  • 1Neuro-Oncology Center, Hospital West, Room 6225, Charlottesville, VA 22908, USA.

Lancet (London, England)
|August 13, 2017
PubMed
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No abstract available in PubMed .

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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