神経ペプチド コラゾニンは 社会的行動と カストアイデンティティを 制御する
Janko Gospocic1, Emily J Shields2, Karl M Glastad1
1Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|August 13, 2017
まとめ
ニューロペプチドであるコラゾニンは 昆虫の社会的な行動を制御します 低調化により 働きアリは 繁殖ゲートとなり 存在すると 働きアリのような行動が促進されます
科学分野:
- 神経倫理学
- 社会的な昆虫の行動
- 遺伝子調節
背景:
- 社会的な昆虫は 共有されたゲノムにもかかわらず 多様な行動を示します
- カースト特有の遺伝子調節を理解することは 社会的な昆虫の行動の鍵です
- ハーペナトスのサルタータは ゲーマーゲート状態に 移行できる
研究 の 目的:
- ハーペグナトスのサルタターのカスト特有の行動の分子メカニズムを調査する.
- ワーカーからゲーマーゲートへの移行に関与する重要な神経ペプチドを特定する.
- 社会的な昆虫のカストのアイデンティティと行動を規制するコラゾニンの役割を決定する.
主な方法:
- ワーカーからゲーマーへの移行中の脳トランスクリプトーム分析
- コラゾニン神経ペプチド濃度の定量化
- ニューロペプチドの注射実験を 移行期のアリで行いました
- 狩り,デュエリング,産卵を測定する行動分析
主要な成果:
- コラゾニンニューロペプチドは,ワーカーからゲーマーゲートへの移行中にダウンレギュレーションされます.
- コラゾニンは,種ごとに働きアリで優遇的に発現する.
- コラゾニンの注射は ゲーマーゲイトの行動を抑制し 労働者のような狩りを促進する
- コラゾニンの注射は 脳内のビテロゲニンの発現を抑制する.
結論:
- コラゾニンは社会的な昆虫の カストアイデンティティと行動の 重要なレギュレータとして作用します
- コラゾニンの微分発現は 行動の可塑性を促す 重要な分子メカニズムです
- この研究は 社会的組織の神経生物学的な基礎に 洞察を与えてくれます
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