セリアック病と非セリアック性グルテン感受性: レビュー
Maureen M Leonard1,2, Anna Sapone1,2,3, Carlo Catassi1,2,4,5
1Center for Celiac Research and Treatment, Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, Massachusetts.
JAMA
|August 16, 2017
まとめ
グルテンに関連した疾患である целиакияや非 целиакияのグルテン過敏症は一般的です グルテンフリーダイエットの前に正確な診断を行うことは 効果的な長期的な管理と潜在的な合併症のモニタリングに不可欠です
科学分野:
- 胃腸内科
- 免疫学
- ダイエット医学
背景:
- グルテン関連の疾患は 増加しています
- 多くの個人は自己診断を行い,グルテンフリーダイエットをする.
- 症状が重なり合っているため,セリアック症と非セリアック性グルテン過敏症を区別することは困難です.
研究 の 目的:
- セリアック症および非セリアック性グルテン過敏症のスクリーニング,診断,治療に関する現在の証拠をレビューする.
- 適切な患者管理のための正確な診断の重要性を強調する.
- ダイエット開始が診断の正確さに与える影響を強調する.
主な方法:
- グルテン関連疾患に関する最新の科学文献のレビュー
- セリアック病と非セリアック性グルテン過敏症の診断基準の分析
- 臨床的表現,遺伝的マーカー,および自己抗体に関する議論
主要な成果:
- セリアック病は,特定の遺伝的および血清学的マーカーを持つ免疫媒介性腸病です.
- 非乳房性グルテン過敏症には 検証されたバイオマーカーがないため 診断と研究が困難です
- セリアック病と非セリアック性グルテン過敏症の症状は,臨床的に区別できない.
- 精密な検査のために,グルテンフリーダイエットの実施前に,乳がんのスクリーニングを行う必要があります.
結論:
- 乳がんや乳がん以外のグルテン過敏症は,グルテンフリーダイエットが必要な一般的な症状です.
- この2つの条件を区別することは,適切な長期的な管理に不可欠です.
- セリアック病の患者は,アデバーンス,栄養状態,および併発性疾患を注意深く監視する必要があります.
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