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Updated: Apr 15, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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CMTM6とCMTM4をPD-L1タンパク質の調節体として識別する

Riccardo Mezzadra1, Chong Sun1, Lucas T Jae2

  • 1Division of Molecular Oncology &Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Nature
|August 17, 2017
PubMed
まとめ

研究者らは,転移したがんのPD-L1発現を制御するタンパク質であるCMTM6を発見しました. CMTM6はPD- L1を安定させ,T細胞の反応を抑制する能力を高め,がん治療の新たな標的となる.

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