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Updated: Feb 24, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

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哺乳類は内生的な遺伝子毒性ホルムアルデヒドを単炭素代謝に転換する

Guillermo Burgos-Barragan1, Niek Wit1, Johannes Meiser2

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Nature
|August 17, 2017
PubMed
まとめ

葉酸を補充すると 有毒な副産物であるホルマルデヒドが生成されます このホルムアルデヒドを排毒することで 細胞の成長に不可欠な 単一炭素単位が得られます 特に他の代謝経路が欠けている細胞ではそうです

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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s07:38

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