人間の癌トランスクリプトームの病理アトラス
Mathias Uhlen1,2,3, Cheng Zhang4, Sunjae Lee4
1Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden. mathias.uhlen@scilifelab.se.
Science (New York, N.Y.)
|August 19, 2017
まとめ
癌の進行は遺伝子発現の変化と関連しています. 短い生存期間は 細胞成長遺伝子の増加と 分化遺伝子の減少と相関し 個別化医療の必要性を強調しています
科学分野:
- 腫瘍学
- ゲノミクス
- システム生物学
背景:
- 癌は世界的に死亡の主な原因です
- 腫瘍特有の分子機構を理解することは 効果的な治療に不可欠です
- システムレベルの分析は 複雑な生物学的プロセスへの洞察を提供します
研究 の 目的:
- 17種類の主要ながんにおける全ゲノム遺伝子発現と臨床結果の関係を調査する.
- 患者の生存に関連した 分子パターンを特定します
- パーソナライズド医療のための癌の代謝異質性を探求する.
主な方法:
- タンパク質をコードする遺伝子の全ゲノムトランスクリプトーム解析
- 遺伝子発現と患者の生存の相関分析
- ゲノムスケールの代謝モデルの構築と分析.
主要な成果:
- 一貫したパターンが観察されました: 細胞成長遺伝子の上調と下調の差異化遺伝子の関連した患者の生存期間が短縮されました.
- 癌患者の間で顕著な代謝異質性が確認された.
- 臨床結果に対するタンパク質の影響を調査するためのインタラクティブなオープンアクセスデータベースの開発.
結論:
- 細胞の成長と分化に関連する遺伝子発現パターンは,がん患者の生存を決定する重要な要因です.
- 代謝の異質性は,個別化されたがん治療の必要性を強調しています.
- プロテイン・アトラスデータベースは,がんの病理学と臨床結果を研究する研究者に貴重なリソースを提供します.
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