植物におけるポリコンブ遺伝子の静止を保持するDNA複製結合ヒストンの改変

Danhua Jiang¹, Frédéric Berger²

¹Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

Science (New York, N.Y.)

|August 19, 2017

まとめ

植物では,ヒストン変種H3.1を用いてDNA複製中にH3K27me3の表遺伝子マークを復元する. このメカニズムは細胞分裂に際して記憶を静止する遺伝子を確保し発達に不可欠です

科学分野:

分子生物学
エピジェネティクス
植物学

背景:

細胞循環の進行には遺伝子発現パターンの維持が必要です
DNA複製はエピジェネティックマークを半分に減らし迅速な復元を必要とします
ヒストンH3ライシン27トリメチル化 (H3K27me3) は重要な転写抑制マーカーである.

研究の目的:

複製する植物細胞における H3K27me3 回復のメカニズムを調査する.
細胞分裂を通して伝達されるエピジェネティックな記憶を理解する
H3K27me3の植物発達の移行における役割を明らかにする.

主な方法:

ヒストン変異体H3.1のDNA複製結合変異を調査した.
植物細胞におけるH3K27me3の回復を分析した.
このメカニズムが花期に移行する際の役割を調べました

主要な成果:

DNA複製中にH3K27me3をH3.1経由で復元するメカニズムを特定した.
植物がH3.1で効率的なK27トリメチル化プロセスを有することを実証した.
このメカニズムは静止記憶を子細胞に伝達するのに不可欠です

結論:

植物は,複製後にH3K27me3の表遺伝子マークを復元する特定のメカニズムを進化させた.
ヒストン変種H3.1は,H3K27me3の複製結合復元に中心的です.
このプロセスは発芽などの発達過程に不可欠なエピジェネティックな記憶の継承を保証します

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