神経前駆体由来プレオトロフィン媒介子 グリオマによる腹腔下部領域の侵入
Elizabeth Y Qin1, Dominique D Cooper1, Keene L Abbott2
1Department of Neurology, Stanford University, Palo Alto, CA 94305, USA.
Cell
|August 22, 2017
まとめ
膠原腫細胞は,神経前駆細胞 (NPC) から信号を受け取って,脳の下腹部領域 (SVZ) に広がります. タンパク質プレオトロフィンとそのパートナーをターゲットにすれば この侵入を阻止できます
科学分野:
- 神経科学
- 腫瘍学
- 細胞生物学
背景:
- 子宮下部 (SVZ) は,小児と成人の両方の患者に,グリオマが広がる一般的な部位である.
- 精密な細胞および分子メカニズムは,SVZの膠原菌の植民を駆動し,大部分は未知のままです.
研究 の 目的:
- グリオマ細胞がSVZに侵入するメカニズムを解明する
- 潜在的治療標的を特定し,SVZへのグリオマの広がりを制限する.
主な方法:
- 神経前駆体細胞 (NPC) - 膠原細胞通信の分析
- 生物化学的,タンパク質的,機能的分析により,分泌される因子を特定する.
- プレイオトロフィンのノックダウンを用いたマウスモデルでの in vivo 研究
- グリオマRho/ROCKシグナル伝達経路の調査
主要な成果:
- NPCは 化学誘導物質の信号を分泌し 膠原細胞を SVZに誘導します
- Pleiotrophinは,SPARC/SPARCL1およびHSP90Bとともに,この化学吸引効果を媒介する.
- SVZにおけるグリオマの侵入を大幅に減少させた.
- プライオトロフィンは,グリオマのRho/ ROCKシグナル伝達を活性化し,ROCK抑制は侵入を減少させた.
結論:
- グリオマ細胞のSVZへの侵入は,NPCとグリオマ細胞の間のコミュニケーションによって引き起こされます.
- プレオトロフィンは,SVZへのグリオマ細胞の化学吸引の重要な媒介です.
- NPC: グリオマの相互作用とプレオトロフィンは,グリオマの侵入を抑制する潜在的な治療目標です.
関連する概念動画
Phagocytosis
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Enteric Nervous System: Regulation of GI Motor Activity
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...
Pathophysiology of Vomiting
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
Peritoneum
The peritoneum is a vital membrane that lines the abdominal cavity and covers most of the organs within it. It plays a crucial role in protecting the organs, providing a smooth surface for their movement, and facilitating various physiological processes. Understanding the anatomy and function of the peritoneum is essential for comprehending the complexities of the abdominal region.
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...
Anatomy of the Peritoneum
The peritoneum is divided into two layers: the parietal peritoneum and the visceral...
Nerve Supply of the GI Tract
The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of the GI tract...
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of the GI tract...
Physiology of the Gastrointestinal System I: Ingestion and Propulsion
The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.


