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エピゲノム・ワイド・アソシエーション・スタディは,心臓の遺伝子パターンを特定し,心臓不全のための新しいバイオマーカーのクラス

Benjamin Meder1, Jan Haas1, Farbod Sedaghat-Hamedani1

  • 1From Department of Internal Medicine III, Institute for Cardiomyopathies, University of Heidelberg, Germany (B.M., J.H., F.S.-H., E.K., K.F., A.L., R.N., C.S., S.M., D.M.-B., A.A., H.H., D.B.H., M.M.-H., T.W., H.A.K.); Siemens Healthcare GmbH, Strategy and Innovation, Erlangen, Germany (C.D., M.W., A.E.P.); Department of Bioinformatics, University of Saarland, Saarbrücken, Germany (A.K.); German Centre for Cardiovascular Research, Berlin, Germany (B.M., J.H., F.S.-H., E.K., K.F., A.L., D.S., M.M.-H., T.W., J.B., H.A.K.); Institute for Molecular Cardiology and Epigenetics, University of Heidelberg, Germany (D.S., J.B.); Funktionelle Genomanalyse, Deutsches Krebsforschungszentrum, Heidelberg, Germany (A.B.); Department of Cardiac Surgery, University of Heidelberg, Germany (A.R.); Siemens AG, Corporate Technology, Vienna, Austria (D.P.); Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Austria (D.P.); and Division of Epigenomics and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany (D.W., C.P.).

Circulation
|August 26, 2017
PubMed
まとめ

この研究では,拡張性心筋病患者のDNAメチル化と遺伝子発現を分析することによって,心不全の新たな表皮遺伝的バイオマーカーを特定しました. これらの発見は表遺伝的調節を強調しています.

キーワード:
DNAメチル化バイオマーカー拡大心筋病エピジェネティクス心不全ナトリウレティックペプチド

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