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Updated: Feb 24, 2026

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
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プリオンのようなドメインによるBAF複合体の癌特異的な再ターゲティング

Gaylor Boulay1, Gabriel J Sandoval2, Nicolo Riggi3

  • 1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Cell
|August 29, 2017
PubMed
まとめ

BRG1/ BRM関連因子 (BAF) 複合体は,EWS- FLI1融合タンパク質によって誘発され,ユーイング肉腫におけるEWSR1と相互作用する. EWSR1のプリオンのようなドメインは,腫瘍性遺伝子の活性化のためにBAF複合体を勧誘する鍵です.

キーワード:
EWS-FLI1 についてユーイング・サーコマ強化剤エピジェネティクス本質的に無秩序なタンパク質mSWI/SNF (BAF) コンプレックスマイクロサテライトの繰り返し段階移行パイオニア・ファクタープリオンのようなドメイン

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