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関連する概念動画

The Significance of Membrane Transport01:44

The Significance of Membrane Transport

43.0K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
43.0K
Primary Active Transport01:29

Primary Active Transport

15.0K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
15.0K
Primary Active Transport01:47

Primary Active Transport

201.9K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
201.9K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

9.9K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
9.9K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

6.7K
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.7K
Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

7.1K
The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
7.1K

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関連する実験動画

Updated: Feb 23, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

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分子機械が細胞膜を開く

Víctor García-López1,2, Fang Chen3, Lizanne G Nilewski1,2

  • 1Department of Chemistry, Rice University, Houston, Texas 77005, USA.

Nature
|September 1, 2017
PubMed
まとめ

分子機械はナモメカニカルな作用で細胞膜を通過し 制御された物質の放出と細胞死を可能にします この物理的方法は,現在の化学的戦略を超えて,生物医学的な応用のための新しい可能性を提供します.

さらに関連する動画

Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
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Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy

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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

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関連する実験動画

Last Updated: Feb 23, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

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Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence TIRF Microscopy
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

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科学分野:

  • バイオ物理学
  • ナノテクノロジー
  • 細胞生物学

背景:

  • 電気場,温度,超音波のような物理的な技術は 細胞膜を操作して 化合物を放出したり 細胞死を誘導したりします
  • 分子モーターとスイッチは,バイオメディカルアプリケーションにおける機械的な動作のための制御された形状の変化を提供します.

研究 の 目的:

  • 分子機械が 細胞の二重層に穴を開けることを 証明するために
  • 制御された物質の拡散,細胞死の誘導,および標的の配送のための分子機械の使用を調査する.

主な方法:

  • 脂質二層に設計された分子モーターを吸収し 紫外線で活性化します
  • 合成小胞から化学物体の拡散を誘導するナモメカニカル作用を利用する.
  • 生体細胞に 追跡可能な 分子装置を導入し 死滅や化学薬品の投与を誘導する

主要な成果:

  • 細胞膜に穴を開けました
  • 細胞から細胞へ 制御された化学物質の拡散が示されています
  • ペプチド改変分子装置を使って 細胞表面の標的を 選択的に標的にしました
  • 生体細胞でナモメカニカル作用による死滅を誘発する.

結論:

  • 分子機械は,ナノメカニカル作用を用いて細胞の二重層を効果的に破ることができます.
  • この物理的アプローチは,細胞内および細胞間物質交換のための新しい方法を提供します.
  • 将来の開発では,高度な活性化方法による in vivo 応用が可能になるかもしれない.