糖尿病における網膜血管機能不全を媒介する循環型非コーディングRNA HIPK3
Kun Shan1, Chang Liu1, Bai-Hui Liu1
1From Eye Institute, Eye and ENT Hospital, Shanghai Medical College, Fudan University, China (K.S., C.L., X.L., S.-J.Z., J.-J.W., S.-H.Z., J.-H.W., C.Z., B.Y.); Fourth School of Clinical Medicine, Nanjing Medical University, China (C.L.); Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China (B.-H.L., R.D.); Department of Ophthalmology, First Affiliated Hospital of Nanjing Medical University, China (X.C.); Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, China (Y.-Y.Z.); Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (B.L.); and Shanghai Key Laboratory of Visual Impairment and Restoration, China (C.Z., B.Y.).
Circulation
|September 2, 2017
PubMed で要約を見る
まとめ
円周RNA circHIPK3は糖尿病において上調され,miR- 30aを阻害することによって網膜血管機能不全を促進する. circHIPK3をターゲットにすることで,糖尿病性網膜症の新たな治療法が提供される可能性があります.
