腸内微生物群は,NFIL3と昼夜時計を通して体構成を調節する
Yuhao Wang1, Zheng Kuang1, Xiaofei Yu1
1Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
まとめ
腸内微生物群は,昼夜転写因子NFIL3を制御することによって,体脂肪に影響を与えます. このタンパク質は腸内の脂質代謝と吸収を調節し 腸内細菌と宿主のエネルギーバランスを結びつけます
科学分野:
- 微生物学
- メタボリズム
- クロノバイオロジー
背景:
- 腸内微生物群は哺乳類のエネルギー貯蔵と体脂肪の蓄積に影響を与える重要な環境要因です.
- 腸内微生物群が宿主体の構成を 調節する正確なメカニズムは ほとんど不明です
研究 の 目的:
- 腸内微生物群が体調を調節するメカニズムを解明する.
- 腸内微生物群,昼夜リズム,宿主の代謝の間の 分子関係を特定する.
主な方法:
- 体組成に対する微生物群の作用を媒介する昼間転写因子NFIL3の役割を調査した.
- 腸内皮質細胞の昼間の遺伝子発現パターンを分析した.
- グループ3の先天性リンパ球とSTAT3の信号がNFIL3の昼夜振動に与える影響を調べました.
主要な成果:
- 微生物群は,昼夜転写因子NFIL3を通じて体構成を調節する.
- NFIL3の転写は,微生物群によって調節される腸内上皮細胞の昼間振動を示している.
- NFIL3は昼夜中の脂質代謝プログラムを制御し,脂質の吸収と排出に影響を与えます.
結論:
- 腸内微生物群は,NFIL3を通して宿主体の組成を調節する.
- NFIL3は,微生物群,昼夜時計,宿主の脂質代謝を結びつける重要な分子リンクとして機能する.
- この経路を理解することで,微生物群と宿主の代謝相互作用に関する機械的洞察が得られます.
さらに関連する動画
関連する概念動画
Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
Anatomy of the Intestines
88.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
88.4K
Bacterial Flora of the Large Intestine
1.8K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K
Regulation of Food Intake
3.0K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.0K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
Enteric Nervous System: Regulation of GI Motor Activity
2.0K
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
2.0K


