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Updated: Feb 23, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

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MC1Rのパルミトイレーション依存の活性化により,メラノーマゲネシスが防止される

Shuyang Chen1, Bo Zhu1, Chengqian Yin1

  • 1Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

Nature
|September 5, 2017
PubMed
まとめ

メラノコルチン-1受容体 (MC1R) のパルミトイレーションを活性化すると,赤毛の色変異が回復し,色素化が増加し,メラノーマの発症が予防されます. この発見は,MC1R変異と関連したメラノーマのリスクに対する潜在的な治療戦略を提供します.

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells06:09

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