バッチとフロー反応のための金属有機フレームワークの化学的安定性,触媒的活性,およびエナチオ選択性の強化
Xu Chen1, Hong Jiang1, Bang Hou1
1School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University , Shanghai 200240, China.
Journal of the American Chemical Society
|September 6, 2017
まとめ
先進的な異質非対称な触媒の設計は極めて重要です この研究では,リガンド設計を使用して高性能金属有機フレームワーク (MOF) を設計し,重要な有機反応の調整可能な安定性,活性,選択性を達成した.
科学分野:
- 材料科学
- カタリシス
- 有機化学
背景:
- 異質な触媒は,高い活性,選択性,再利用性を有する触媒を設計する上で課題に直面しています.
- メタル・オーガニック・フレームワーク (MOF) は,調整可能な構造により,触媒の開発に有望なプラットフォームを提供します.
研究 の 目的:
- MOFに基づいたリガンド設計戦略を使用して高性能の異質非対称な触媒を設計する.
- MOFの化学的安定性,触媒的活性,ステレオ選択性に対するリガンド改変の影響を調査する.
主な方法:
- 異なるフェニル置換剤 (トリフローロメチル,メチル,フローロ) を用いたエナティオピュア・フォスフォノカルボキシラートリガンドを用いた3つの多孔性キラルMOF ([Mn2L(H2O) 2) の合成.
- アルキル化反応のためのバッチとフロー反応システムのMOF性能の評価.
- 同様の同質な触媒との比較
主要な成果:
- リガンド改変により,MOFの化学的安定性,触媒的活性,ステレオ選択性がうまく調整されました.
- トリフローロメチル (-CF3) 基を持つMOFは,水,弱酸,塩基に対する耐性が向上した.
- CF3を含むMOFは優れた反応性,選択性,および再利用性を示し,アルキル化反応において高いエナチオ選択性を示した.
- 均質な触媒は,試験反応に対する低エナンチオ選択性を示した.
結論:
- リガンド設計は,MOFから高性能の異質非対称な触媒を設計するための効果的な戦略です.
- CF3機能化されたMOFは,非対称性アルキル化のための優れた触媒であり,同質な同位体よりも優れている.
- この研究は,安定した,選択的,再利用可能な異質な触媒の開発を進めています.
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