刺激性腸症候群における管機能の異常
Lancet (London, England)
|August 29, 1987
まとめ
自律神経系の機能不全は,イライラ性腸症候群 (IBS) 患者によく見られ,腸および心臓機能の両方に影響します. これらの神経系異常は,胃食道逆流や運動性問題などの一般的なIBS症状を説明する可能性があります.
科学分野:
- 胃腸内科 胃腸内科
- 自律神経科学とは
- クリニカル・メディシン 臨床医学
背景:
- 刺激性腸症候群 (IBS) は,一般的な機能性胃腸障害である.
- 自律神経系 (ANS) 機能障害は,IBSの病理生理学に潜在的に寄与するものとしてますます認識されています.
- ANSの関与を理解することは,ターゲットを絞った治療法の開発に不可欠です.
研究 の 目的:
- IBS患者における栄養および心臓の自律神経機能を調査する.
- IBSにおける自律機能障害の有病率を決定する.
- 自律的機能障害と胃腸の症状または発見の関係を探求する.
主な方法:
- 25人のIBS患者と25人の対照群で,腹部圧縮に対する陰道媒介下側食道門の圧力反応を評価した.
- 23人のIBS患者のインスリン誘発性低血糖症とペンタガストリンの刺激試験を使用して,エフェルント管機能の評価.
- 23人のIBS患者で深呼吸中の脈拍の変動を測定した.
- 自律機能テストの結果と内視検査結果 (食道炎) と胃食道逆流 (pHモニタリング) が相関しています.
主要な成果:
- 25人のIBS患者のうち13人は,コントロールと比較して,下側食道門の圧力の陰道媒介による増加が減少したことを示した.
- 23人のIBS患者のうち7人の中で,不正常なエフェルント管機能が観察されました.
- 深呼吸による脈拍の変動の低下は,IBS患者23人中6人に認められた.
- 自律的なテストの異常は食道炎や胃食道逆流と強く相関していない.
結論:
- 自律神経反射の異常は,IBS患者で一般的です.
- これらの自律機能障害は,IBSにおける胃食道逆流の頻発に寄与する可能性があります.
- 自律神経系の機能不全は,IBSの特徴である胃腸運動障害に役割を果たす可能性があります.
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