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Updated: Feb 23, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
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Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

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ドーパミンの酸化は,パーキンソン病におけるミトコンドリアおよびリソソーム機能障害を媒介する

Lena F Burbulla1,2, Pingping Song1, Joseph R Mazzulli1,2

  • 1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Science (New York, N.Y.)
|September 9, 2017
PubMed
まとめ

ミトコンドリアの酸化ストレスがドーパミンの酸化を引き起こし,パーキンソン病 (PD) のヒトニューロンにおけるミトコンドリアとリソソーム機能障害を結びつける. 酸化ドーパミンと 減少したグルコセレブロシダスが関わるこのカスケードは PDの神経変異を誘発します

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