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Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
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小さな 分子は,本質的に 乱れた タンパク質 の 構成 格局 に 変化 を もたらす

David Ban, Luigi I Iconaru, Arvind Ramanathan1

  • 1Computational Science and Engineering Division, Health Data Sciences Institute, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37830, United States.

Journal of the American Chemical Society
|September 9, 2017
PubMed
まとめ

本質的に乱れたタンパク質 (IDP) は複数の状態を動的にサンプリングします. p27-D2への小さな分子結合は,エネルギーバリアを変えることなくこれらの集団をシフトさせ,IDPの相互作用に関する新しい洞察を提供します.

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