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Updated: Feb 23, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

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腫瘍性ウイルス治療は,腫瘍内T細胞の浸透を促進し,抗PD-1免疫療法を改善する

Antoni Ribas1, Reinhard Dummer2, Igor Puzanov3

  • 1University of California at Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.

Cell
|September 9, 2017
PubMed
まとめ

タリモゲンラヘルパレプベックとペンブロリズマブ (抗PD-1療法) を併用した腫瘍解消性ウイルス治療は,進行性メラノーマ患者で62%の客観的な応答率を示した. この組み合わせ療法により,T細胞の浸透が強化され,抗PD-1治療の有効性が改善される可能性があります.

キーワード:
Tリンパ球アンチPD-1バイオマーカー細胞毒性インターフェロン・ガンマメラノーマ腫瘍性免疫療法腫瘍性ウイルスペンブロリズマブタリモゲン・ラハーペルベック腫瘍腫瘍の微小環境

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