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Updated: Feb 23, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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チオエステル交換によるアミノ酸残基のヘリックス傾向

Brian F Fisher1, Seong Ho Hong1, Samuel H Gellman1

  • 1Department of Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

Journal of the American Chemical Society
|September 13, 2017
PubMed
まとめ

この研究は,アミノ酸ヘリックス傾向をデナチュラントなしで確実に測定するための新しいチオエステル交換方法を導入しています. この技術は,標準的および非標準的アミノ酸のアルファヘリックス形成を正確に定量化します.

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Amino acids03:42

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Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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