薬物分子の結合と放出をプログラムするための多変量金属有機フレームワーク
Zhiyue Dong1, Yangzesheng Sun1, Jun Chu1
1Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences, and ‡UC Berkeley-Wuhan University Joint Innovative Center, The Institute of Advanced Studies, Wuhan University , Luojiashan, Wuhan 430072, China.
Journal of the American Chemical Society
|September 13, 2017
まとめ
金属有機フレームワーク (MOF) から ゲスト分子の放出をプログラムしました 毛穴の相互作用を調整することでです これにより,機能化されたMOFを使用して予測可能で制御可能な薬物投与プロファイルができます.
科学分野:
- 材料科学
- 超分子化学
- ナノテクノロジー
背景:
- 多孔性物質から ゲスト分子の放出を制御することは 薬の投与などの用途において 極めて重要です
- メタル・オーガニック・フレームワーク (MOF) は,調節可能な孔環境を提供しますが,放出運動を正確に制御することは依然として困難です.
研究 の 目的:
- 機能化されたMOFからプログラム可能なゲスト分子の放出を,ゲストと毛穴の相互作用を制御することによって実証する.
- 機能群の性質と放出率の定数との量的な相関を確立する.
- 薬物放出プロファイルと複数の分子の同時放出を正確に制御する.
主な方法:
- MIL-101 (Fe) を基に一連の機能化された金属有機フレームワーク (MOF) を合成し,アミン (-NH2) とカーボキシラート (-C4H4) の割合を変化させた.
- これらのMOFから3つの探査分子 (イブプロフェン,ロダミンB,ドクソルビシン) の放出運動を研究した.
- MOFの毛穴内の機能群の種類と割合と量的に相関する放出率の定数.
主要な成果:
- ロダミンBの放出率をMIL-101から32倍に調整した.
- ドクソルビシンの放出ピークを40日間で最大12日間,MIL-101 (Fe) - (C4H4) x (NH2) - (x) MOFから移動させた.
- 一つのMOFシステムから2つのプロドラッグ分子 (イブプロフェンとドクソルビシン) の相次ぎが成功していることが実証されました.
結論:
- ゲスト分子の放出プロファイルは,機能化されたMOF内でゲスト-毛穴の相互作用をチューニングすることによって正確に制御できます.
- 開発されたMOFシステムは,物理的な混合物または他の多孔性材料と比較して,放出運動に対する優れた制御を提供します.
- このアプローチは,治療薬の予測可能でプログラム可能な投与を可能にします.
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