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cGASは,タンパク質-DNAの梯子を形成することによって,長い,HMGB/TFAMに結合したUターンDNAを感知します

Liudmila Andreeva1,2, Björn Hiller1,2, Dirk Kostrewa1,2

  • 1Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

Nature
|September 14, 2017
PubMed
まとめ

サイクルGMP-AMP合成酵素 (cGAS) は,先天的な免疫のためにDNAの長さを感知します. HMGB1やTFAMのようなDNA結合タンパク質は,病原体やミトコンドリアDNAの識別に不可欠な長いDNAをcGASで検出するのに役立ちます.

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