D. melanogasterのセグメンタル特異と表皮の発達には,複合的な遺伝的場所,ポリホメオティックが必要である
J M Dura1, N B Randsholt, J Deatrick
1Centre de Génétique Moleculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Cell
|December 4, 1987
まとめ
ポリホメオティック (ph) 遺伝子は,ゼロ効果のために2つの変異を必要とし,複雑性を示します. DNA分析により,ph遺伝子の機能に不可欠な重複配列が明らかになり,新しい遺伝的メカニズムが示唆されました.
科学分野:
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
背景:
- ポリホメオティック (ph) 遺伝子は,胚の発達に極めて重要です.
- phのゼロ変異は,胚の致死性と特定の表皮派生体の喪失につながります.
- シングルイベント変異は,既知の発達遺伝子に類似した,支配的な機能獲得フェノタイプを示します.
研究 の 目的:
- ポリホメオティック (ph) ロッカスの遺伝的複雑性を調査する.
- ph遺伝子機能の分子基礎とその異常な変異の要件を理解するために.
- 場所の機能的組織のためのモデルを提案する.
主な方法:
- 染色体歩行によるポジショナルのクローニングにより,ph遺伝子を局所化する.
- DNAの再編成によるph変異の分析.
- 複合化研究は,ph領域の繰り返しDNA要素を特定するために行われます.
主要な成果:
- ph遺伝子は,欠陥と再配列誘発変異を用いて局所化された.
- 2つの大きな複製されたDNA配列が,ph locus.内で特定されました.
- 複製された配列のいずれかの病変は,ph遺伝子機能を破壊し,その重要性を確認します.
結論:
- ポリホメオティック (ph) ローカスは遺伝的に複雑で,ゼロフェノタイプには2つの変異性イベントが必要です.
- 複製された配列の存在は,正常なph遺伝子機能に不可欠である.
- 異常な機能的組織とph locus.の遺伝的要件を説明するためのモデルが提案されています.
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