正常な発達とインヴォルションの異常 (ANDI):良性乳腺疾患の病原性と命名に関する新しい視点
L E Hughes1, R E Mansel, D J Webster
1University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff.
Lancet (London, England)
|December 5, 1987
まとめ
新しいフレームワークである正常な発達と転移の異常 (ANDI) は,良性乳房疾患を正常な乳房プロセスからのわずかな偏差として説明します. このアプローチは,乳腺の状態をより正確に評価するのに役立ち,線維腫症のような時代遅れの用語を置き換えます.
科学分野:
- 乳腺の健康について
- 病理学 パトロジー
- 婦人科 婦人科について
背景:
- 良性乳腺疾患は一般的であり,様々な用語を使って診断されることが多い.
- 既存の分類は,病原性を理解するための統一された枠組みがない.
- "繊維胞性疾患"のような用語は不正確で,さまざまな状態を網羅しています.
研究 の 目的:
- 乳腺の良性疾患を理解するための新しい概念的枠組みを導入する.
- 乳腺問題の評価と管理に統一されたアプローチを確立する.
- 曖昧な用語は,病原性に基づいた記述用語に置き換える.
主な方法:
- 生理学的過程に基づく新しい分類システムの開発.
- 新しい枠組みにおける臨床的および組織学的発見の統合.
- 常見の乳房の苦情の再評価は,正常な発達とインヴォルション (ANDI) の偏差の概念を用いて行われました.
主要な成果:
- 標準的な発達とインボリューションの偏差 (ANDI) フレームワークは,発達的,周期的,およびインボリューション的プロセスに基づいて,乳房疾患を分類します.
- このアプローチは,乳腺異常を分類するためのより論理的で一貫した方法を提供します.
- ANDIは,正常な変異と病理的な状態の明確な区別を容易にする.
結論:
- ANDIフレームワークは,良性乳腺疾患に対する科学的に堅実で臨床的に有用なアプローチを提供します.
- ANDI用語の採用は,より明確なコミュニケーションと,より正確な患者評価を促進します.
- この概念的シフトは,不正確な歴史的用語から病原遺伝学的な理解へと移ります.
関連する概念動画
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...