(3-アミノ-1-ヒドロキシプロピリデン) -1,1-ビスホスフォネート (APD) を使用してステロイド誘発性骨粗鬆症の予防
関連する実験動画
Updated: Aug 18, 2026
08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
I R Reid1, A R King, C J Alexander
1Department of Medicine, University of Auckland, New Zealand.
Lancet (London, England)
|January 23, 1988
まとめ
この研究では,アミノヒドロキシプロピリデンビスホスフォネート (APD) が,長期にわたるグルココルチコイド療法を受けている患者の骨の損失を予防し,1年以上にわたって骨質を維持することを発見しました.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 骨代謝についてです.
- 薬理学 薬理学とは
背景:
- 長期にわたるグルココルチコイド治療は,骨の減少と関連しています.
- グルココルチコイドは骨の改造を妨害し,骨折のリスクを高めます.
研究 の 目的:
- 長期にわたるグルココルチコイド治療を受けている患者における骨の損失を予防する (3-アミノ-1-ヒドロキシプロピリデン) -1,1-ビスホスフォネート (APD) の有効性を評価する.
- 骨質の保存において,APDとカルシウムとカルシウムのみを比較する.
主な方法:
- プロスペクティブ,ランダム化,プラセボ対照試験.
- 150mg/日APDと1g/日カルシウムと,カルシウムだけで摂取する.
- 骨の質量は,12ヶ月間にわたってメタカルパの皮質領域と脊椎の鉱物密度 (定量計算機断層撮影) によって評価されています.
主要な成果:
- APDグループは6ヶ月でメタカルパの皮質面積が1.2%増加し,安定したままでしたが,プラセボは減少した (p<0.05).
- 脊椎のミネラル密度はAPD群で19.6%増加 (p<0.02) したが,対照群では8.8%減少 (p<0.005).
- バイオケミカルマーカーと骨ヒストモルフォメトリーは,骨の再吸収と骨形成の減少を示し,オステオマラシアは認められませんでした.
結論:
- APDは,12ヶ月間にわたって長期にわたるグルココルチコイド治療を受けている患者の骨の損失を効果的に予防します.
- APDは,プラセボと比較して,皮質と脊椎の両方の骨質の保存に有意な利点を示しています.
関連する概念動画
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...