ウイルス後疲労症候群の患者における慢性エンテロウイルス感染症

G E Yousef¹, E J Bell, G F Mann

¹Department of Pathology, St Mary's Hospital Medical School, London.

Lancet (London, England)

|January 23, 1988

まとめ

慢性エンテロウイルス感染症は,後ウイルス性疲労症候群 (PVFS) で一般的です. 血清内のエンテロウイルス抗原を検出することは,PVFS患者にとって効果的な診断方法です.

科学分野:

ウイルス学ウイルス学ウイルス学
免疫学免疫学とは
感染症感染症は感染症です.

背景:

ポストウイルス性疲労症候群 (PVFS) は,しばしばウイルス感染症に続く衰弱状態です.
PVFSの病原性における持続性ウイルス感染症の役割は,依然として調査中です.

研究の目的:

PVFSの患者におけるエンテロウイルス感染の有病率を調査する.
PVFSを診断するために,血清内のエンテロウイルス抗原を検出する有用性を評価する.

主な方法:

糞便サンプルからウイルスを分離し,特定のモノクローナル抗体を用いて血清内のエンテロウイルスVP1抗原を検出する.
VP1抗原検出に関連したIgM複合体の存在の分析.
陽性ウイルス培養を持つ患者の長期追跡.

主要な成果:

エントロウイルスは,PVFS患者の22%から,対照群の7%と比較して分離されました.
エントロウイルスVP1抗原は,PVFS患者の51%の血清で検出され,IgM複合体が存在すると陽性性が高くなりました.
1年後,患者のサブセットで持続的なエンテロウイルス感染症が確認されました.

結論:

慢性腸ウイルス感染症は,多くのPVFS症例において重要な要因である.
血清エンテロウイルス抗原検出は,PVFSを調査するための敏感で実用的なアプローチを提供します.

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