コリックの発生に関する研究

M A Stokes¹, K J Moriarty, B N Catchpole

¹University Department of Surgery, Hope Hospital, Salford, Manchester, England.

Lancet (London, England)

|January 30, 1988

まとめ

腸内ではしばしば経験されるコリックの痛みは,特定の腸内セグメント内の圧力変化に関連しています. この研究は,この不快感の特徴と位置を明らかにし,胃腸の痛みメカニズムについての洞察を提供します.

科学分野:

胃腸内科胃腸内科
神経胃腸内科神経胃腸内科
Visceral Pain Research (内臓の痛みに関する研究)

背景:

コリックは腹痛の一般的な原因ですが,その正確な内臓の起源と特徴は未だに不完全です.
腸内内イベントと痛みの知覚の関係を理解することは,効果的な管理に不可欠です.

研究の目的:

局所的な腸内イベントと痛みの知覚,特に大腸痛との関係を調査する.
実験的に誘発された腸の痛みの空間的 (位置,長さ) と時間的 (期間) 特徴を決定する.

主な方法:

軽度の相性痛は,1人の正常なボランティアと12人の腸疾患の患者で,気球膨張と様々な腸部位に塩分注射を用いて誘発された.
研究期間中,内圧力は継続的に記録されました.
参加者は,圧力変化と相関する痛みの経験を報告しました.

主要な成果:

痛みは,長さ632cmの腸部に圧力が上昇したときにのみ知覚されました.
痛みを伴う圧力の上昇は,痛みを伴わない局所的な上昇よりも低いことが多い.
誘発された相性痛はコリックの特徴を示し,小腸と大腸の両方で通常1分未満に続きます.

結論:

コリックを模倣する腸内痛は,特定の腸内セグメント内の圧力変動と関連しています.
巻き込まれた腸断片の長さと圧力変化の特徴は,痛みの知覚の重要な要因です.
痛みの発症はしばしばパラセントラルに発生し,重度が高まるにつれて中線に広がります.

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