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Updated: Jan 23, 2026

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Published on: October 3, 2025

EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) は,骨髄由来の血管新生生因子であり,心筋梗塞後の組織修復を促進する

Marc R Reboll¹, Mortimer Korf-Klingebiel¹, Stefanie Klede¹

¹From Division of Molecular and Translational Cardiology, Department of Cardiology and Angiology (M.R.R., M.K.-K., S.K., E.B., I.R., Y.W., K.C.W.), Core Unit Proteomics, Institute of Toxicology (F.P., A.P.), Department of Biophysical Chemistry (J.F.), Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiothoracic, Transplantation, and Vascular Surgery (G.K., I.G.), Institute of Legal Medicine (M.K.), Institute of Physiological Chemistry (M.G.), and Department of Cardiology and Angiology (J.B.), Hannover Medical School, Germany; F. Hoffmann-La Roche, Pharma Research and Early Development, Basel, Switzerland (H.-J.S., M.B.); Department of Pathology and Department of Cardiac Surgery, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands (H.W.N.); and Department of Physiology and Cellular Biophysics and Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY (J.A.G.).

|September 22, 2017

まとめ

エンドプラズマ網膜タンパク質複合体10 (EMC10) は新しい血管新生因子である. 心筋梗塞の後の心臓の修復を促すため,血管の形成が改善されます.

科学分野:

心血管生物学
再生医療
分子心臓科

背景:

骨髄細胞療法による心筋梗塞 (MI) の有効性は限られている.
骨髄細胞から分泌されるタンパク質は心臓の修復のための潜在的な代替手段を提供します
EMC10 (endoplasmic reticulum membrane protein complex subunit 10) は新しい血管新生タンパク質として特定されました.

研究の目的:

心筋梗塞におけるEMC10の血管新生の可能性と治療的役割を調査する.
Emc10の細胞源と信号伝達経路を定義する.
心臓発作後の心不全の治療法として再結合 Emc10 を評価する.

主な方法:

内皮細胞と心臓のエクスペラントを用いたインビトロ試験.
野生型のEmc10欠乏症および骨髄キメリックマウスにおけるインビボ試験.
心不全のマウスモデルにおける再結合 Emc10 の治療用投与

主要な成果:

Emc10は,p38 MAPK-MK2信号伝達を介して,内皮細胞の移動と血管新生を促進する.
ヒトとマウスの脳内発作後,Emc10の発現は心臓と循環に上昇する.
Emc10欠乏症は心臓の修復を阻害し, Emc10治療は改善する.

結論:

Emc10は,心臓発作後の心臓修復に関与する新しい血管新生成長因子です.
骨髄由来モノサイトとマクロファージは,Emc10の主要な源である.
Emc10の治療強化は心臓病の治療に有望である.

キーワード:

血管新生骨髄炎症モノサイト心筋梗塞

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