イミドとイミニルの窒素中枢レドックスによるC-H結合アミネーション効率の直接比較

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Updated: Jan 11, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

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Matthew J T Wilding1, Diana A Iovan1, Alexandra T Wrobel1

  • 1Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|September 23, 2017
PubMed
まとめ

鉄イミドとイミニル複合体は合成され,特徴づけられました. イミドからイミニル種への酸化は,アルキルイミニルがアリルイミニルよりも反応性があるため,トルーエンの活性化バリアを下げます.

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Imines are formed under mildly acidic conditions. A pH of 4.5 is ideal for the reaction.
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