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刺激性ダイナミクスとヤップ依存のメカニカルシグナルがセグメンテーションクロックを駆動する
Alexis Hubaud1, Ido Regev2, L Mahadevan3
1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch 67400, France; Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA.
Cell
|September 26, 2017
まとめ
脊椎動物のセグメンテーションはセグメンテーションクロックに依存しています この研究では 振動は 細胞の集合的特性であり 定数感知と 機械的なシグナルによって引き起こされ 時計は興奮しやすいシステムであることを示しています
科学分野:
- 発達生物学
- 細胞動態
- 遺伝学
背景:
- 脊椎動物の体軸をソミットと脊椎に分割することは,分割時計に依存する.
- セグメンテーションクロックは,プレソミティック・メソデルマ (PSM) のリズム信号伝達経路の活動を含む.
- これらの振動が単細胞に固有のものか,集団現象であるかは不明である.
研究 の 目的:
- セグメンテーションクロック振動が単細胞か集団レベルの性質であるかどうかを調査する.
- 安定した細胞振動を観察するための in vitro 培養条件を確立する.
- これらの振動を誘発するクオラムセンシングと 機械的なヒントの役割を探る
主な方法:
- 安定した細胞振動を達成するために,in vitro培養条件を開発した.
- ヤップとノッチの信号経路を利用して 振動を誘発した
- 細胞状態を変えるために ヤップ依存の機械的なシグナルを操作した
主要な成果:
- セグメンテーションクロックの振動がPSM細胞の集合的性質であることを示した.
- 振動はダイナミックなクオラムセンシング信号で in vitro で活発に誘発されることが示されています.
- 孤立したPSM細胞を静止状態から振動状態に切り替えることが確認された.
結論:
- セグメンテーションクロックは 興奮するシステムとして機能します
- 振動は細胞の集合的行動であり 単細胞の内在的な性質ではありません
- 脊椎動物の形態変異のダイナミクスを研究するための新しいパラダイムを紹介する.
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