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目標指向の運動スキルのための皮質脊髄回路の解体
Xuhua Wang1, Yuanyuan Liu1, Xinjian Li2
1F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Cell
|September 26, 2017
まとめ
空間的に組織された皮質脊髄ニューロン (CSN) は,マウスの熟練した前肢の動きの異なる側面を制御します. これらのニューロン群は 連続的に活性化して 運動のタスクの 達成,捉え,移行段階を 管理します
科学分野:
- 神経科学
- モーター コントロール
- 計算神経科学
背景:
- 皮質から脊髄に信号を伝達する 脊髄神経細胞 (CSN) は 運動制御に不可欠です
- 複雑な運動タスクにおけるCSN機能を支配する組織的原則は,大部分が未定義のままである.
研究 の 目的:
- 熟練した前肢運動の作業におけるCSNの組織原理を明らかにする.
- 地域特有のCSNの役割を特定する.
主な方法:
- CSNを特定し,研究するためにマウスの逆行式ラベリングシステムを利用した.
- 熟練した前肢のタスクの実行中にCSNの活動を監視するために in vivoイメージングを実行します.
- 異なるCSN群の機能的貢献を評価するために,地域特有の遺伝子操作を使用した.
主要な成果:
- CSNの活動は,タスクの実行中に地形的に組織された機能アンサンブルの連続的なアクティベーションを示した.
- 前足の尻尾部からのCSNは,到達するのに不可欠であり,ロストラルのCSNは,掴むのに不可欠でした.
- 尾関節と頭関節の両方のCSNは,移行プロネーション運動のために必要でした.
- 地域特有のCSNは,特定のタスクフェーズに関与する前運動神経をターゲットに,異なる脊髄レベルに投影されます.
結論:
- 空間的に定義されたCSNグループは,熟練した動きのための異なるモーターモジュールをコードします.
- この空間的組織は 複雑な運動能力を調整する 脊髄皮質の回路の枠組みを提供します
- 発見は前肢制御のための皮質脊髄管内の正確なソマトトピック組織を明らかにします.
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