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Updated: Feb 22, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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SIRT2は,病理性心筋縮における心臓保護性デアセチラーゼとして作用する

Xiaoqiang Tang1, Xiao-Feng Chen1, Nan-Yu Wang1

  • 1Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (X.T., X.-F.C., N.-Y.W., X.-M.W., S.-T.L., W.Z., X.Z., D.-L.H., Z.-Q.Z., H.-Z.C., D.-P.L.).

Circulation
|September 27, 2017
PubMed
まとめ

Sirtuin 2 (SIRT2) タンパク質は,心不全でダウンレギュレーションされます. SIRT2の喪失は心臓の過剰増殖を悪化させ,その過剰発現は心臓を保護する. SIRT2は心臓不全の潜在的治療標的である.

キーワード:
AMPK についてLKB1 についてSIRT2 について老化するアンジオテンシンII心臓の大幅縮小デセチル化メトホルミン

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