異種性抗体とアトピー性疾患

A M Collins¹

¹Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.

Lancet (London, England)

|April 2, 1988

まとめ

食品からの異種抗体は消化に生き残り,ヒトの免疫系に影響を与える可能性があります. これは,乳製品消費に関連した花粉などの環境物質に対するアレルギーを説明するかもしれません.

科学分野:

免疫学免疫学とは
食品科学食品科学について

背景:

異種抗体は,生物学的活動を保持し,食品加工を生き延びることができます.
これらの抗体は腸から吸収され,ヒトの抗原と抗体として機能します.
抗イディオタイプを含む抗牛ガンマグローブリン (BGG) 抗体は,ヒトの血清に含まれています.

研究の目的:

異種抗体がどのようにしてヒトの免疫系を活性化させるのかについての仮説を提唱する.
食事による異種性抗体と環境アレルゲンに対するアレルギーの関連性を調査する.

主な方法:

文献レビューと仮説の立案.
抗体の吸収と免疫機能の分析.

主要な成果:

異種抗体は吸収され,ヒトの免疫系に影響を与えることができます.
低レベルの曝露は,アレルゲンに対する不適切な反応のために免疫システムを準備する可能性があります.
乳製品は,食中の異種性抗体の重要な源である.

結論:

食品中の異種性抗体は,牛乳タンパク質以外のアレルギーの発生に寄与する可能性があります.
異種性抗体への食事による暴露は,環境アレルギーとの関連を説明する可能性がある.

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