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Updated: Feb 22, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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標的治療のための大量並列のデノボタンパク質設計

Aaron Chevalier1,2, Daniel-Adriano Silva1,2, Gabriel J Rocklin1,2

  • 1Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

Nature
|September 28, 2017
PubMed
まとめ

この研究では,ミニタンパク質の結合剤を設計するための新しい計算および実験方法が紹介されています. これらの安定した形状のタンパク質は 治療対象に対して高い親和性を示し インフルエンザに対して強力な保護を提供する.

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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