パルバルブミンとソマトスタチン・インターニューロンは,中枢腸内皮質の異なる空間コードネットワークを制御する
Chenglin Miao1, Qichen Cao1, May-Britt Moser1
1Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, MTFS, 7489 Trondheim, Norway.
Cell
|October 3, 2017
まとめ
パルバルブミン (PV) 内ニューロンを静止させると,中枢内皮質 (MEC) のグリッド細胞パターンが破壊される. ソマトスタチン (SOM) インターニューロン静止は,非周期的な発火場を持つ細胞を損なうので,空間的コーディングにおける明確な役割を明らかにする.
科学分野:
- 神経科学
- 計算神経科学
- システム神経科学
背景:
- 空間ナビゲーションには 中間内皮質 (MEC) が不可欠です
- パルバルブミン (PV) およびソマトスタチン (SOM) タイプを含むGABAergicインターニューロンは,MEC回路の重要な構成要素です.
- MECの空間表現におけるこれらのインターニューロンクラスの特定の役割は完全に理解されていません.
研究 の 目的:
- PVとSOMを表現するインターニューロンがMECの空間コード化に与える異なる貢献を調査する.
- 格子細胞の発火および他の空間的に調節された活動パターンの基礎となる細胞メカニズムを解明する.
主な方法:
- 自由に動くマウスのPVまたはSOM内ニューロンを選択的に静止させるための薬剤遺伝的アプローチを使用した.
- 空間ナビゲーションのタスク中に電気生理学を使用してMECのニューロンの活動を記録します.
- 内部ニューロン静止がグリッド・セル,スピード・セル,非周期的な発射場を持つ細胞に与える影響を分析した.
主要な成果:
- PVインターニューロンの静止は,MECグリッド細胞の,特にレイヤIIの,六角形の空間的選択性を破壊し,速度細胞の調節を損なった.
- SOM 内ニューロンの静止はグリッドや速度セルに影響を与えなかったが,無周期的な発射フィールドを持つ細胞の空間的選択性を低下させた.
- PVとSOMのインターニューロンの静音化は,境界細胞やヘッド・ディレクション・セルに影響を与えなかった.
結論:
- PVとSOMのインターニューロンは,MEC内の空間表現の形成において,異なる,重複しない役割を果たします.
- PVインターニューロンは,グリッド細胞の周期的な発火パターンと速度調節に不可欠です.
- SOM 内ニューロンは,他のMEC細胞タイプで観察された無周期的空間コーディングに関与する.
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