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Updated: Feb 22, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

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化学 プロテオミクスは,遺伝的に定義された癌の薬効性のある脆弱性を特定する

Liron Bar-Peled1, Esther K Kemper1, Radu M Suciu1

  • 1The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cell
|October 3, 2017
PubMed
まとめ

研究者は,KEAP1変異を有する非小細胞肺がん (NSCLC) の新しい標的としてNR0B1を特定しました. NR0B1を標的にする小さな分子は癌細胞の成長を阻害し,これらの肺がんに対する新たな治療法を提供している.

キーワード:
KEAP1 についてNR0B1NRF2 について活動に基づくプロファイリング化学プロテオミクスコバランスフラグメント肺がんマススペクトロメトリー

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