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Updated: Feb 21, 2026

Delivery of Proteins, Peptides or Cell-impermeable Small Molecules into Live Cells by Incubation with the Endosomolytic Reagent dfTAT
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バイオリバーシブルエステル化によるタンパク質の細胞分解

Kalie A Mix1, Jo E Lomax, Ronald T Raines1

  • 1Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

Journal of the American Chemical Society
|October 5, 2017
PubMed
まとめ

タンパク質は,カルボキシル群を水害性分子で覆い隠すことで哺乳類の細胞に入ることができる. このエステル化法により タンパク質は前薬のように作用し 細胞溶液に入り 本来のタンパク質を再生します

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