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Updated: Feb 21, 2026

CIRCLE-Seq for Interrogation of Off-Target Gene Editing
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CRISPR-Cas13によるRNAターゲティング

Omar O Abudayyeh1,2,3,4,5, Jonathan S Gootenberg1,2,3,4,6, Patrick Essletzbichler1,2,3,4

  • 1Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

Nature
|October 5, 2017
PubMed
まとめ

科学者はCRISPR-Cas13aを 哺乳類の細胞で精密なRNA操作のために設計しました この新しいツールは,既存の方法よりも高い特異性で,標的型RNAノックダウンと生細胞トランスクリプト追跡を提供します.

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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