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癌の薬物依存は,ERK2依存のフェノタイプスイッチによって伝達される

Xiangjun Kong1, Thomas Kuilman1, Aida Shahrabi1

  • 1Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Nature
|October 5, 2017
PubMed
まとめ

BRAF阻害剤に依存した癌細胞は,ERK2,JUNB,FRA1を含む経路を利用します. MITFのシャットダウンを含むこの経路を妨害することで,治療中止時に細胞死亡を防ぐことができ,薬剤耐性がんに対する新しい治療戦略を提供します.

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