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カリブレーションされたミトス振動器は運動性シリオゲネシスを駆動する

Adel Al Jord^1,2,3, Asm Shihavuddin^1,2,3, Raphaël Servignat d'Aout^1,2,3

¹Institut de Biologie de l'École Normale Supérieure (IBENS), Paris Sciences et Lettres (PSL) Research University, Paris F-75005, France.

Science (New York, N.Y.)

|October 7, 2017

まとめ

非分裂細胞は,分化中にオルガネルの改造を管理するために,細胞分裂"時計"を利用する. CDK1-APC/Cによって調節されるこのミト動振動器は,細胞分裂を誘発することなく,センチオールの生成とシリエーションを誘導します.

科学分野:

細胞生物学
発達生物学
分子生物学

背景:

細胞分裂と分化には重要な臓器の改造が伴う.
サイクリン依存キナーゼ1-アナフェーズ促進複合体/サイクロソーム (CDK1-APC/C) を含むミトス振動器は,細胞分裂中の臓器の再編成を調整する.

研究の目的:

非分裂細胞が分化に関連したオルガネルの改造のために細胞分裂制御回路を利用するかどうかを調査する.
マウス脳多シリア細胞の分化過程におけるセンチオール増幅におけるミトス振動器の役割を探求する.

主な方法:

マウスの脳で多胞体細胞の分化におけるセンターロール増幅の研究.
細胞の分化と細胞サイクル進行への影響を観察するために,サイクリン依存キナーゼ1 (CDK1) 活性を操作した.

主要な成果:

ミトスの後の祖先は,有秩序なセンチオール産生,成熟,シリエーションのためにミトスの振動器活動を校正した.
CDK1の活動が不足すると分化が妨げられ,CDK1の活動が過剰になると分化が加速するが,ミトーシスが誘発される.
非分裂細胞はミトス振動器を再利用し,細胞膜と核のダイナミクスを切り離し,臓器を再構成する.

結論:

ミトスの後の細胞は,分化特有の臓器の再構築のためにミトスの振動器を適応させることができる.
核分裂から独立した細胞プラズマの再編成を可能にする.
このメカニズムは様々な細胞プロセスにおける細胞循環調節体の柔軟性を強調しています

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