フェロプトーシス: 代謝,レドックス 生物学,病気 を 結びつける 制御 さ れ た 細胞 死亡 の 繋がり
Brent R Stockwell1, José Pedro Friedmann Angeli2, Hülya Bayir3
1Department of Biological Sciences, Columbia University, 550 West 120(th) Street, MC 4846, New York, NY 10027, USA; Department of Chemistry, Columbia University, 550 West 120(th) Street, MC 4846, New York, NY 10027, USA.
Cell
|October 7, 2017
まとめ
制御された細胞死であるフェロプトーシスには,鉄に依存した脂質過酸化が含まれます. フェロプトーシスメカニズムを理解することは 退行性疾患や潜在的な癌治療への洞察にとって不可欠です
科学分野:
- 細胞生物学
- 生物化学
- 病理学について
背景:
- フェロプトーシスは,鉄に依存した脂質水酸化物蓄積によって制御される細胞死経路である.
- 細胞膜の多不飽和脂肪酸に関連した 古代の細胞の脆弱性から生じています
- 細胞には この脆弱性を管理する 複雑なシステムがあります
研究 の 目的:
- フェロプトーシスの分子メカニズムを見直す
- 生物学的プロセスや病気との関係を調べる
- フェロプトーシスを研究するためのガイドラインを提供するためです.
主な方法:
- このレビューは,フェロプトーシスメカニズムに関する現在の研究をまとめています.
- メタボリック経路 (アミノ酸,鉄,PUFA,グルタチオン,NADPH,CoQ10) にフェロプトーシスを接続する.
- フェロプトーシスの様々な病理学的作用と潜在的治療的応用について考察している.
主要な成果:
- フェロプトーシスは神経変性,癌,臓器損傷を含む多くの疾患に関連しています.
- 病的な細胞死と潜在的腫瘍抑制の両方に関与しています.
- 代謝調節障害はフェロプトーシスの感受性に大きく影響する.
結論:
- フェロプトーシスは,健康と病気に広範な影響を及ぼす重要な細胞死経路です.
- フェロプトーシスをターゲットにすることで 癌や退行性疾患の 治療戦略が生まれます
- 臨床的利益のためにフェロプトーシスを完全に解明し,活用するにはさらなる研究が必要です.
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