S2前およびB型肝炎ウイルスの抗体反応は,肝臓損傷を誘発した
A Alberti1, D Cavalletto, P Pontisso
1Istituto di Medicina Clinica, University of Padova, Italy.
Lancet (London, England)
|June 25, 1988
まとめ
B型肝炎ウイルス (HBV) のS2前配列に対する抗体は,ウイルスクリアランスのマーカーです. 彼らの存在は回復を示し,急性または慢性B型肝炎感染症の肝臓損傷には寄与しません.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 免疫学 免疫学とは
- 肝臓病理学 肝臓病理学
背景:
- B型肝炎ウイルス (HBV) の封筒には,S2以前のコード化された配列が含まれています.
- B型肝炎の感染と回復におけるS2前抗体の役割は完全に理解されていません.
研究 の 目的:
- B型肝炎ウイルス (HBV) 感染症におけるS2前配列に対する抗体の重要性を調査する.
- 抗プレ-S2抗体が肝臓疾患の活動または病原性に関連しているかどうかを判断する.
主な方法:
- 急性および慢性B型肝炎患者のS2以前の抗体検出
- 疾患の進化,肝臓損傷,ワクチン接種者との関係における抗体の存在の分析.
- 自己免疫反応の評価と,抗HBs応答への影響.
主要な成果:
- pre-S2に対する抗体は,急性B型肝炎の患者の83%で発見されました.
- これらの抗体は,慢性的な症例では存在せず,慢性的なB型肝炎ではまれ (<10%),疾患活動とは無関係であった.
- Anti-pre-S2抗体は,回復後何年も持続し,免疫力のある健康な個体に存在し,特定のワクチンによって誘発され,副作用はありませんでした.
結論:
- pre-S2に対する抗体反応は,B型肝炎ウイルス (HBV) クリアランスのマーカーとして機能する.
- Anti-pre-S2抗体は,HBVに関連する肝損傷の病原生に作用しません.
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