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確認された妊婦の赤血球性母性赤血球のアウトカム

G Enders¹, U Nickerl-Pacher, E Miller

¹Institut für Medizinische Virologie und Infektionsepidemiologie, Stuttgart, Federal Republic of Germany.

Lancet (London, England)

|June 25, 1988

まとめ

最後の月経 (LMP) の12日前までの母性赤毛感染症は,胎児へのリスクが最小です. しかし,LMPの3~6週間後に発生した赤毛は,子宮内感染症と先天性赤毛症候群のリスクを大幅に増加させます.

科学分野:

産婦人科と産婦人科を担当しています.
感染症感染症は感染症です.
小児科は小児科です.

背景:

妊娠中のラベッラ感染症は,胎児に深刻な合併症を引き起こす可能性があります.
最後の月経周期 (LMP) に関する母性赤毛感染のタイミングを理解することは,胎児リスクの評価に不可欠です.

研究の目的:

LMPに関連して,母性発疹の発症のタイミングに基づいて子宮内赤毛感染症のリスクを将来的に評価する.
母性赤毛の発症タイミングと胎児のアウトカム (先天性赤毛症候群を含む) の間の相関を決定する.

主な方法:

LMPの5週間前から6週間後に発生した赤血球が確認された61人の妊婦の将来のフォローアップ.
39例で妊娠中絶と赤血球ウイルスに対する胎児組織検査を行いました.
帯血清検査で,22例の終末期IgM抗体を特定した.

主要な成果:

LMP前またはその後の11日以内に母性発疹が現れた場合,子宮内感染症は検出されなかった.
胎児感染は,LMPの12日後に発生しました.
LMP の3~6週間後に発疹を発症した10人の妊娠はすべて胎児感染をもたらし,満期に生まれた4人の乳児は先天性損傷を持っていた.

結論:

LMP の前または直後に発生したルベッラ感染は,胎児感染のリスクは無視できる.
LMPの3〜6週間後の母性赤毛感染症は,胎児感染と先天性異常のリスクが高い.
妊婦のラベッラ感染のタイミングの適時な評価は,高リスク妊娠の管理に不可欠です.

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