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Updated: Feb 21, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
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EGFRリガンドは受容体ダイマーを差異的に安定させ,シグナリング運動を特定する

Daniel M Freed1, Nicholas J Bessman2, Anatoly Kiyatkin1

  • 1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA.

Cell
|October 10, 2017
PubMed
まとめ

異なった表皮成長因子受容体 (EGFR) リガンドであるエピレグルリン (EREG) とエピゲン (EPGN) は,異なったEGFR二分化を引き起こす. この部分的アゴニズムは持続的なシグナル伝達につながり,乳がんの増殖に対する細胞分化を促進します.

キーワード:
バイアスアゴニスト細胞の運命決定クリスタルグラフィーディメリゼーション成長因子運動校正ネガティブなフィードバックリン酸塩レセプターチロシンキナーゼ信号特異性

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