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Updated: Feb 21, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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リンソームのカルシウム浸透性チャンネルTRPML3の冷凍電子顕微鏡構造

Marscha Hirschi1, Mark A Herzik2, Jinhong Wie3

  • 1Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.

Nature
|October 12, 2017
PubMed
まとめ

TRPML3チャネルの構造は,ムコリピンのドメインがフォスファディチリノシトール-3,5-ビスホスファート (PtdIns(3,5) P2) を結合してカルシウム (Ca2+) の流れを活性化する方法を示しています. この発見は,脂質依存型TRPMLチャネルゲートのメカニズムを明らかにする.

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Purification and Reconstitution of TRPV1 for Spectroscopic Analysis11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

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