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Updated: Feb 21, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

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TAPBPR-MHC I複合体の構造は,ペプチドのロードと編集のメカニズムを定義する

Christoph Thomas1, Robert Tampé1,2

  • 1Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue Strasse 9, 60438 Frankfurt/Main, Germany. c.thomas@em.uni-frankfurt.de tampe@em.uni-frankfurt.de.

Science (New York, N.Y.)
|October 14, 2017
PubMed
まとめ

メジャー・ヒストコンパティビリティ・コンプレックスクラスI (MHC I) チャペロン,タパシン (Tsn) とTAP結合タンパク質関連 (TAPBPR) は,免疫反応を制御する. TAPBPR-MHC I構造は,MHC I溝を改造することによって,TAPBPRがペプチドを選択する方法を明らかにします.

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