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Updated: May 4, 2026

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors

Published on: September 10, 2013

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CESTによるCoII2 MRIプローブによる比率測定 pHイメージング 反対のpH依存性の効果

Agnes E Thorarinsdottir1, Kang Du1, James H P Collins2

  • 1Department of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.

Journal of the American Chemical Society
|October 14, 2017
PubMed
まとめ

研究者は,化学交換飽和移転 (CEST) を使用した比率測定 pH イメージングのための新しいコバルト-2 ベースのプローブを開発しました. この二核型トランジションメタルプローブは,濃度独立のpH測定を提供しており,in vivo試験の有望性を示しています.

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pH01:24

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A buffer can prevent a sudden drop or increase in the pH of a solution after the addition of a strong acid or base up to its buffering capacity; however, such addition of a strong acid or base does result in the slight pH change of the solution. The small pH change can be calculated by determining the resulting change in the concentration of buffer components, i.e., a weak acid and its conjugate base or vice versa. The concentrations obtained using these stoichiometric calculations can be used...
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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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