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Updated: May 8, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

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Published on: April 30, 2021

ニボルマブによる免疫療法における腫瘍と微小環境の進化

Nadeem Riaz1, Jonathan J Havel2, Vladimir Makarov3

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|October 17, 2017
PubMed
まとめ

ニボルマブによる免疫チェックポイント阻害は,メラノーマにおける新抗原に対する突然変異と選択によって腫瘍の進化を変化させます. この治療法では 腫瘍の免疫微小環境を形作り T細胞の反応を高めます

キーワード:
T細胞受容体レパートリークロンの進化/クロンの選択免疫療法イピリムマブメラノーマネオアンチゲン負荷ニボルマブ腫瘍の免疫回避腫瘍の微小環境腫瘍変異負荷/腫瘍変異負荷

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