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Updated: May 6, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

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コレステロール合成を抑制するオキシステロールは,AIM2炎症体の活性化を阻害する

Eric V Dang1, Jeffrey G McDonald2, David W Russell2

  • 1Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143-0795, USA.

Cell
|October 17, 2017
PubMed
まとめ

I型インターフェロンは,コレステロール25ヒドロキシラーゼ (Ch25h) を上調することで炎症を抑制する. この研究は,25-ヒドロキシコレステロール (25-HC) の生成が炎症体の活性化を阻害し,ミトコンドリアの完全性を維持し,AIM2の活性化を阻害することを示しています.

キーワード:
25-ヒドロキシコレステロールAIM2 についてCh25h についてIL-1βSREBP についてコレステロール炎症ゾームマクロファージミトコンドリアオキシステロール

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NMR-Based Activity Assays for Determining Compound Inhibition, IC50 Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases10:24

NMR-Based Activity Assays for Determining Compound Inhibition, IC50 Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases

Published on: June 30, 2019

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