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Updated: May 5, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

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細胞サイクルとタンパク質品質管理における異型ユビキチン鎖の組立と機能

Richard G Yau1, Kerstin Doerner2, Erick R Castellanos3

  • 1Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, Berkeley, CA, USA.

Cell
|October 17, 2017
PubMed
まとめ

研究者は,特定のユビキチン鎖 (K11/K48関連) を検出する新しい抗体を開発した. この発見は 細胞循環の調節と 神経変性疾患に関連するタンパク質を含む 誤った折りたたまれたタンパク質の除去における 重要な役割を明らかにしています

キーワード:
ハンティングチンハンティントン病アナフェーズ促進複合体枝分かれしたユビキチン鎖プロテアソームタンパク質の品質管理ユビキチンユビキチン鎖

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